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Article

Notch Signaling Contributes to the Expression of Cardiac Markers in Human Circulating Progenitor Cells

25 Oct 2007

Abstract excerpt

It has been demonstrated that adult human circulating endothelial progenitor cells (EPCs) can differentiate to a cardiomyogenic phenotype. Notch signaling promotes epithelial-to-mesenchymal transformation and plays a role in heart and vessel development. Here, we investigated the role of Notch activation for cardiac differentiation of EPCs in a coculture system with neonatal cardiomyocyte. After coculture, Notch...

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Identifiers

PMID: 17967789
DOI: 10.1161/circresaha.107.151381

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