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Article

A receptor-specific function for Notch2 in mediating vascular smooth muscle cell growth arrest through cyclin-dependent kinase inhibitor 1B.

Circulation research - 27 Sept 2013

Boucher Joshua M, Harrington Anne, Rostama Bahman, Lindner Volkhard, Liaw Lucy

Abstract excerpt

RATIONALE: Deregulated vascular smooth muscle cell (VSMC) proliferation contributes to multiple vascular pathologies, and Notch signaling regulates VSMC phenotype. OBJECTIVE: Previous work focused on Notch1 and Notch3 in VSMC during vascular disease; however, the role of Notch2 is unknown. Because injured murine carotid arteries display increased Notch2 in VSMC as compared with uninjured arteries, we sought to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p27

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Identifiers

PMID: 23965337
DOI: 10.1161/CIRCRESAHA.113.301272
PMCID: PMC3882755

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