Article
RhoA-mediated signaling in Notch-induced senescence-like growth arrest and endothelial barrier dysfunction.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2011
Venkatesh Deepak, Fredette Natalie, Rostama Bahman, Tang Yuefeng, Vary Calvin P H, Liaw Lucy, Urs Sumithra
Abstract excerpt
OBJECTIVE: Notch signaling has a critical role in vascular development and morphogenesis. Activation of Notch in endothelial cells led to a senescence-like phenotype with loss of barrier function. Our objective was to understand the molecular pathways mediating this phenotype. METHODS AND RESULTS: Human primary endothelial cells increase expression of Notch receptors and ligands during propagation in vitro toward...
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