Article
Pharmacogenetic association of MBL2 and CD95 polymorphisms with grade 3 infection following adjuvant therapy for breast cancer with doxorubicin and cyclophosphamide.
European journal of cancer (Oxford, England : 1990) - 1 Jan 2017
Jamieson David, Sunter Nicola, Muro Sara, Pouché Lucie, Cresti Nicola, Lee Johanne, Sludden Julieann, Griffin Melanie J, Allan James M, Verrill Mark W, Boddy Alan V
Abstract excerpt
Life-threatening infection as an adverse reaction to cytotoxic therapy of cancer remains a major problem, potentially limiting efficacy. Administration of colony-stimulation factors benefits only a minority of patients, and improved stratification guidelines are needed to identify those patients likely to benefit. We investigated single nucleotide polymorphisms (SNPs) in two genes related to immune function to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.