Article
Mannose-binding lectin status is associated with risk of major infection following myeloablative sibling allogeneic hematopoietic stem cell transplantation.
Blood - 1 Sept 2008
Mullighan Charles G, Heatley Susan L, Danner Silke, Dean Melinda M, Doherty Kathleen, Hahn Uwe, Bradstock Kenneth F, Minchinton Robyn, Schwarer Anthony P, Szer Jeff, Bardy Peter G
Abstract excerpt
Mannose-binding lectin (MBL) is a mediator of innate immunity that influences the risk of infection in a range of clinical settings. We previously reported associations between MBL2 genotype and infection in a retrospective study of myeloablative allogeneic hematopoietic stem cell transplantation (allo-HCT). However, other studies have been inconclusive, and the role of MBL in reduced-intensity conditioning (RIC)...
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