Association of ABCB1 and SLC22A16 Gene Polymorphisms with Incidence of Doxorubicin-Induced Febrile Neutropenia: A Survey of Iranian Breast Cancer Patients.

doi:10.1371/journal.pone.0168519

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Article

Association of ABCB1 and SLC22A16 Gene Polymorphisms with Incidence of Doxorubicin-Induced Febrile Neutropenia: A Survey of Iranian Breast Cancer Patients.

PloS one - 1 Jan 2016

Faraji Abolfazl, Dehghan Manshadi Hamid Reza, Mobaraki Maryam, Zare Mahkameh, Houshmand Massoud

Abstract excerpt

Breast cancer is the most common cancer in women worldwide. Doxorubicin-based chemotherapy is used to treat breast cancer patients; however, neutropenia is a common hematologic side effect and can be life-threatening. The ABCB1 and SLC22A16 genes encode proteins that are essential for doxorubicin transport. In this study, we explored the effect of 2 common polymorphisms in ABCB1 (rs10276036 C/T) and SLC22A16...

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PMID: 28036387
DOI: 10.1371/journal.pone.0168519
PMCID: PMC5201260

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ABCB1

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