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Article

Relationship between ABCB1 gene polymorphisms and severe neutropenia in patients with breast cancer treated with doxorubicin/cyclophosphamide chemotherapy.

Drug metabolism and pharmacokinetics - 1 Apr 2015

Ikeda Midori, Tsuji Daiki, Yamamoto Keisuke, Kim Yong-Il, Daimon Takashi, Iwabe Yutaro, Hatori Masahiro, Makuta Ryo, Hayashi Hideki, Inoue Kazuyuki, Nakamichi Hidenori, Shiokawa Mitsuru, Itoh Kunihiko

Abstract excerpt

Chemotherapy-induced neutropenia is one of the major adverse events which results in the reduction of chemotherapy. Doxorubicin is a substrate of the adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1) transporter; reportedly, ABCB1 polymorphisms influence doxorubicin pharmacokinetics. We evaluated the association between chemotherapy-induced neutropenia and ABCB1 polymorphisms in patients with...

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Source

Identifiers

PMID: 25989890
DOI: 10.1016/j.dmpk.2014.09.009

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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