Identification of Two Genetic Loci Associated with Leukopenia after Chemotherapy in Patients with Breast Cancer.

doi:10.1158/1078-0432.CCR-20-4774

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Article

Identification of Two Genetic Loci Associated with Leukopenia after Chemotherapy in Patients with Breast Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 2 Aug 2022

Fasching Peter A, Liu Duan, Scully Steve, Ingle James N, Lyra Paulo C, Rack Brigitte, Hein Alexander, Ekici Arif B, Reis Andre, Schneeweiss Andreas, Tesch Hans, Fehm Tanja N, Heinrich Georg, Beckmann Matthias W, Ruebner Matthias, Huebner Hanna, Lambrechts Diether, Madden Ebony, Shen Jess, Romm Jane, Doheny Kim, Jenkins Gregory D, Carlson Erin E, Li Liang, Fridley Brooke L, Cunningham Julie M, Janni Wolfgang, Monteiro Alvaro N A, Schaid Daniel J, Häberle Lothar, Weinshilboum Richard M, Wang Liewei

Abstract excerpt

PURPOSE: To identify molecular predictors of grade 3/4 neutropenic or leukopenic events (NLE) after chemotherapy using a genome-wide association study (GWAS). EXPERIMENTAL DESIGN: A GWAS was performed on patients in the phase III chemotherapy study SUCCESS-A (n = 3,322). Genotyping was done using the Illumina HumanOmniExpress-12v1 array. Findings were functionally validated with cell culture models and the...

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PMID: 35653140
DOI: 10.1158/1078-0432.CCR-20-4774
PMCID: PMC9357161

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