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Article

Impact of genetic polymorphisms determining leukocyte/neutrophil count on chemotherapy toxicity.

The pharmacogenomics journal - 1 Apr 2018

Glisovic S J, Pastore Y D, Gagne V, Plesa M, Laverdière C, Leclerc J M, Sinnett D, Krajinovic M

Abstract excerpt

Neutropenia and infection are major dose-limiting side effects of chemotherapy. The risk of initial infection and subsequent complications are directly related to the depth and duration of neutropenia. Recent genome-wide association studies identified variants in DARC and CXCL2 genes, and in ORMDL3-GSDMA-CSF3 locus on chromosome 17q21 that influence white blood cell and neutrophil counts in healthy individuals....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28534526
DOI: 10.1038/tpj.2017.16

Genes

CXCL2
GSDMA
APC
CSF3
ORMDL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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