Article
Lumican-null mice are susceptible to aging and isoproterenol-induced myocardial fibrosis.
Biochemical and biophysical research communications - 22 Jan 2017
Chen Shao-Wei, Tung Ying-Chang, Jung Shih-Ming, Chu Yen, Lin Pyng-Jing, Kao Winston W-Y, Chu Pao-Hsien
Abstract excerpt
With aging and stress, the myocardium undergoes structural remodeling, often leading to fibrosis. The purpose of this study is to examine whether lumican, one of the class II small leucine-rich proteoglycans, has a protective role in cardiac remodeling and fibrosis. In attempts to elucidate the hypothesis that lumican may have a protective role in cardiac remodeling and fibrosis, we compared the cardiac...
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