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Article

Deriving a cardiac ageing signature to reveal MMP-9-dependent inflammatory signalling in senescence.

Cardiovascular research - 1 Jun 2015

Ma Yonggang, Chiao Ying Ann, Clark Ryan, Flynn Elizabeth R, Yabluchanskiy Andriy, Ghasemi Omid, Zouein Fouad, Lindsey Merry L, Jin Yu-Fang

Abstract excerpt

AIMS: Cardiac ageing involves the progressive development of cardiac fibrosis and diastolic dysfunction coordinated by MMP-9. Here, we report a cardiac ageing signature that encompasses macrophage pro-inflammatory signalling in the left ventricle (LV) and distinguishes biological from chronological ageing. METHODS AND RESULTS: Young (6-9 months), middle-aged (12-15 months), old (18-24 months), and senescent...

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Source

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Identifiers

PMID: 25883218
DOI: 10.1093/cvr/cvv128
PMCID: PMC4498140

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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