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Article

Deficiency of biglycan causes cardiac fibroblasts to differentiate into a myofibroblast phenotype.

The Journal of biological chemistry - 13 May 2011

Melchior-Becker Ariane, Dai Guang, Ding Zhaoping, Schäfer Liliana, Schrader Jürgen, Young Marian F, Fischer Jens W

Abstract excerpt

Myocardial infarction (MI) is followed by extracellular matrix (ECM) remodeling, which is on the one hand required for the healing response and the formation of stable scar tissue. However, on the other hand, ECM remodeling can lead to fibrosis and decreased ventricular compliance. The small leucine-rich proteoglycan (SLRP), biglycan (bgn), has been shown to be critically involved in these processes. During...

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Identifiers

PMID: 21454527
DOI: 10.1074/jbc.M110.192682
PMCID: PMC3089578

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SMAD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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