Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide association across Saccharomyces cerevisiae strains reveals substantial variation in underlying gene requirements for toxin tolerance.

PLoS genetics - 1 Feb 2018

Sardi Maria, Paithane Vaishnavi, Place Michael, Robinson De Elegant, Hose James, Wohlbach Dana J, Gasch Audrey P

Abstract excerpt

Cellulosic plant biomass is a promising sustainable resource for generating alternative biofuels and biochemicals with microbial factories. But a remaining bottleneck is engineering microbes that are tolerant of toxins generated during biomass processing, because mechanisms of toxin defense are only beginning to emerge. Here, we exploited natural diversity in 165 Saccharomyces cerevisiae strains isolated from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomass
Share to Drug Tolerance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fermentation

Share to Gene Knockout Techniques

Share to Genome, Fungal

Share to Lignin

Share to Organisms, Genetically Modified

Share to Toxins, Biological

Source

Open in PubMed Open full text

Identifiers

PMID: 29474395
DOI: 10.1371/journal.pgen.1007217
PMCID: PMC5849340

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide association across Saccharomyces cerevisiae strains reveals substantial variation in underlying gene requirements for toxin tolerance.PMID 29474395Read ↗

Comparative genomics of Saccharomyces cerevisiae natural isolates for bioenergy production.Semantic proximity Read ↗

Genes controlling hydrolysate toxin tolerance identified by QTL analysis of the natural Saccharomyces cerevisiae BCC39850.Semantic proximity Read ↗

Robustness and evolvability in natural chemical resistance: identification of novel systems properties, biochemical mechanisms and regulatory interactions.Semantic proximity Read ↗

Quantitative Trait Loci (QTL)-Guided Metabolic Engineering of a Complex Trait.Semantic proximity Read ↗

Genomic and transcriptome analyses reveal that MAPK- and phosphatidylinositol-signaling pathways mediate tolerance to 5-hydroxymethyl-2-furaldehyde for industrial yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Harnessing genetic diversity in Saccharomyces cerevisiae for fermentation of xylose in hydrolysates of alkaline hydrogen peroxide-pretreated biomass.Semantic proximity Read ↗

A novel AST2 mutation generated upon whole-genome transformation of Saccharomyces cerevisiae confers high tolerance to 5-Hydroxymethylfurfural (HMF) and other inhibitors.Semantic proximity Read ↗

The impact of the genetic background on gene deletion phenotypes in Saccharomyces cerevisiae.Semantic proximity Read ↗

Population-scale chemical response revealed by a barcoded yeast collection.Semantic proximity Read ↗

The chemical genomic portrait of yeast: uncovering a phenotype for all genes.Semantic proximity Read ↗

Evolutionary engineering of Saccharomyces cerevisiae for enhanced tolerance to hydrolysates of lignocellulosic biomass.Semantic proximity Read ↗

Exploiting natural variation in Saccharomyces cerevisiae to identify genes for increased ethanol resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.