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Article

Genetic disruption of NRF2 promotes the development of necroinflammation and liver fibrosis in a mouse model of HFE-hereditary hemochromatosis.

Redox biology - 1 Apr 2017

Duarte Tiago L, Caldas Carolina, Santos Ana G, Silva-Gomes Sandro, Santos-Gonçalves Andreia, Martins Maria João, Porto Graça, Lopes José Manuel

Abstract excerpt

BACKGROUND AND AIMS: In hereditary hemochromatosis, iron deposition in the liver parenchyma may lead to fibrosis, cirrhosis and hepatocellular carcinoma. Most cases are ascribed to a common mutation in the HFE gene, but the extent of clinical expression is greatly influenced by the combined action of yet unidentified genetic and/or environmental modifying factors. In mice, transcription factor NRF2 is a critical...

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Source

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Identifiers

PMID: 27936457
DOI: 10.1016/j.redox.2016.11.013
PMCID: PMC5149069

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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