Article
Hfe acts in hepatocytes to prevent hemochromatosis.
Cell metabolism - 1 Feb 2008
Vujić Spasić Maja, Kiss Judit, Herrmann Thomas, Galy Bruno, Martinache Stefanie, Stolte Jens, Gröne Hermann-Josef, Stremmel Wolfgang, Hentze Matthias W, Muckenthaler Martina U
Abstract excerpt
Hereditary hemochromatosis (HH) is a prevalent, potentially fatal disorder of iron metabolism hallmarked by intestinal hyperabsorption of iron, hyperferremia, and hepatic iron overload. In both humans and mice, type I HH is associated with mutations in the broadly expressed HFE/Hfe gene. To identify where Hfe acts to prevent HH, we generated mice with tissue-specific Hfe ablations. This work demonstrates that...
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