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Article

TFR2 p.A75V mutation aggravates liver iron overload in alcoholic liver disease via ERK pathway.

Journal of molecular medicine (Berlin, Germany) - 12 Feb 2026

Xie Chao, Liu Yingying, Wang Xiaofan, Huang Long, Wang Xiaoming, Zhang Wei, Wu Lina, Liu Tianhui, Wang Ping, Liu Lin, Fan Xu, Jia Jidong, Ou Xiaojuan, Xu Anjian, Cong Min

Abstract excerpt

Liver iron overload, a contributing factor to liver damage, is frequently observed in advanced alcoholic liver disease (ALD). Genetic factors may influence the progression of ALD. This study explored the involvement of hemochromatosis-related genes in liver iron deposition among ALD patients. Clinical data from 97 ALD patients revealed that those with liver iron overload had worse liver function and prognosis....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Liver Diseases, Alcoholic

Share to MAP Kinase Signaling System

Share to Receptors, Transferrin

Source

Identifiers

PMID: 41677839
DOI: 10.1007/s00109-026-02640-6

Genes

TFR2
HAMP
HFE
HJV
SLC40A1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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