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HFE genotype, parenchymal iron accumulation, and liver fibrosis in patients with nonalcoholic fatty liver disease.

Gastroenterology - 1 Mar 2010

Valenti Luca, Fracanzani Anna Ludovica, Bugianesi Elisabetta, Dongiovanni Paola, Galmozzi Enrico, Vanni Ester, Canavesi Elena, Lattuada Ezio, Roviaro Giancarlo, Marchesini Giulio, Fargion Silvia

Abstract excerpt

BACKGROUND & AIMS: Mutations in the hemochromatosis gene (HFE) (C282Y and H63D) lead to parenchymal iron accumulation, hemochromatosis, and liver damage. We investigated whether these factors also contribute to the progression of fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: We studied clinical, histologic (liver biopsy samples for hepatocellular iron accumulation), serologic (iron...

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Source

Identifiers

PMID: 19931264
DOI: 10.1053/j.gastro.2009.11.013

Genes

HFE

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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