Article
Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) signaling. Implications for transferrin-dependent hepcidin regulation.
Haematologica - 1 Nov 2010
Poli Maura, Luscieti Sara, Gandini Valentina, Maccarinelli Federica, Finazzi Dario, Silvestri Laura, Roetto Antonella, Arosio Paolo
Abstract excerpt
BACKGROUND: Impaired regulation of hepcidin in response to iron is the cause of genetic hemochromatosis associated with defects of HFE and transferrin receptor 2. However, the role of these proteins in the regulation of hepcidin expression is unclear. DESIGN AND METHODS: Hepcidin expression, SMAD and extracellular signal-regulated kinase (Erk) phosphorylation and furin expression were analyzed in hepatic HepG2...
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