Article
A New Mouse Strain with a Mutation in the NFE2L2 (NRF2) Gene.
Biochemistry. Biokhimiia - 1 Dec 2023
Egorov Evgeniy S, Kondratenko Natalia D, Averina Olga A, Permyakov Oleg A, Emelyanova Maria A, Prikhodko Anastasia S, Zinovkina Ludmila A, Sergiev Petr V, Zinovkin Roman A
Abstract excerpt
Transcription factor NRF2 is involved in inflammatory reactions, maintenance of redox balance, metabolism of xenobiotics, and is of particular interest for studying aging. In the present work, the CRISPR/Cas9 genome editing technology was used to generate the NRF2ΔNeh2 mice containing a substitution of eight amino acid residues at the N-terminus of the NRF2 protein, upstream of the functional Neh2 domain, which...
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