Article
First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin.
Gut - 1 Jul 2005
Wallace D F, Summerville L, Lusby P E, Subramaniam V N
Abstract excerpt
BACKGROUND: Transferrin receptor 2 (TfR2) is a key molecule involved in the regulation of iron homeostasis. Mutations in humans cause type 3 haemochromatosis and a targeted mutation in mice leads to iron overload with a similar phenotype. We have previously described the generation of a complete TfR2-knockout (KO) mouse. AIMS: The aims of this study were to determine the phenotype and analyse expression of iron...
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