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Histone deacetylase Hos2 regulates protein expression noise by potentially modulating the protein translation machinery.

Nucleic acids research - 22 Jul 2024

Lin Wei-Han, Opoc Florica J G, Liao Chia-Wei, Roy Kevin R, Steinmetz Lars M, Leu Jun-Yi

Abstract excerpt

Non-genetic variations derived from expression noise at transcript or protein levels can result in cell-to-cell heterogeneity within an isogenic population. Although cells have developed strategies to reduce noise in some cellular functions, this heterogeneity can also facilitate varying levels of regulation and provide evolutionary benefits in specific environments. Despite several general characteristics of...

Topics

Gene Expression Regulation, Fungal
Histone Deacetylases
Mutation
Protein Biosynthesis
Ribosomal Proteins
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 38783136
DOI: 10.1093/nar/gkae432
PMCID: PMC11260488

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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