Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway.

Science (New York, N.Y.) - 10 Feb 2006

Bhattacharyya Roby P, Reményi Attila, Good Matthew C, Bashor Caleb J, Falick Arnold M, Lim Wendell A

Abstract excerpt

Scaffold proteins organize signaling proteins into pathways and are often viewed as passive assembly platforms. We found that the Ste5 scaffold has a more active role in the yeast mating pathway: A fragment of Ste5 allosterically activated autophosphorylation of the mitogen-activated protein kinase Fus3. The resulting form of Fus3 is partially active-it is phosphorylated on only one of two key residues in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pheromones
Share to Allosteric Regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Amino Acid Motifs

Share to Crystallography, X-Ray

Share to Down-Regulation

Share to MAP Kinase Signaling System

Share to Mitogen-Activated Protein Kinases

Share to Protein Structure, Secondary

Source

Identifiers

PMID: 16424299
DOI: 10.1126/science.1120941

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway.PMID 16424299Read ↗

Membrane localization of scaffold proteins promotes graded signaling in the yeast MAP kinase cascade.Semantic proximity Read ↗

The scaffold protein Ste5 directly controls a switch-like mating decision in yeast.Semantic proximity Read ↗

Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms.Semantic proximity Read ↗

Quantitative effect of scaffold abundance on signal propagation.Semantic proximity Read ↗

Dual role for membrane localization in yeast MAP kinase cascade activation and its contribution to signaling fidelity.Semantic proximity Read ↗

A role for autophosphorylation revealed by activated alleles of FUS3, the yeast MAP kinase homolog.Semantic proximity Read ↗

Localized feedback phosphorylation of Ste5p scaffold by associated MAPK cascade.Semantic proximity Read ↗

Fus3-triggered Tec1 degradation modulates mating transcriptional output during the pheromone response.Semantic proximity Read ↗

Persistent activation by constitutive Ste7 promotes Kss1-mediated invasive growth but fails to support Fus3-dependent mating in yeast.Semantic proximity Read ↗

Control of MAPK signaling specificity by a conserved residue in the MEK-binding domain of the yeast scaffold protein Ste5.Semantic proximity Read ↗

Phenotypic and transcriptional plasticity directed by a yeast mitogen-activated protein kinase network.Semantic proximity Read ↗

MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.