Article

Selective functional inhibition of a tumor-derived p53 mutant by cytosolic chaperones identified using split-YFP in budding yeast

2021-04-04

Abstract excerpt

<h4>ABSTRACT</h4> Life requires the oligomerization of individual proteins into higher-order assemblies. In order to form functional oligomers, monomers must adopt appropriate three-dimensional structures. Molecular chaperones transiently bind nascent or misfolded proteins to promote proper folding. Single missense mutations frequently cause disease by perturbing folding despite chaperone engagement. A misfolded...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 896bfc3a-0aa4-5c03-904a-099aabdda9ae
DOI: 10.1101/2021.04.02.438278

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Selective functional inhibition of a tumor-derived p53 mutant by cytosolic chaperones identified using split-YFP in budding yeastDOI 10.1101/2021.04.02.438278Read

Selective functional inhibition of a tumor-derived p53 mutant by cytosolic chaperones identified using split-YFP in budding yeast.Semantic proximity Read

Chaperone Requirements for De Novo Folding of <i>Saccharomyces cerevisiae</i> SeptinsSemantic proximity Read

Cytosolic chaperones mediate quality control of higher-order septin assembly in budding yeast.Semantic proximity Read

Sequestration of TDP-43 <sup>216-414</sup> aggregates by cytoplasmic expression of the proSAAS chaperoneSemantic proximity Read

Functional analysis of p53 tumor suppressor in yeast.Semantic proximity Read

Molecular chaperones: Guardians of tumor suppressor stability and function.Semantic proximity Read

Dominant gain-of-function mutations in Hsp104p reveal crucial roles for the middle region.Semantic proximity Read

Phase Separation and Prion‐Like Aggregation of p53 Family Tumor Suppressors: From Protein Evolution to Cancer TreatmentSemantic proximity Read

Biallelic mutations in WRAP53 result in dysfunctional telomeres, Cajal bodies and DNA repair, thereby causing Hoyeraal-Hreidarsson syndrome.Semantic proximity Read

The Hsp70/Hsp90 Co-Chaperone Hop/Stip1 Shifts the Proteostatic Balance from Folding Towards DegradationSemantic proximity Read

Chaperone-dependent stabilization and degradation of p53 mutants.Semantic proximity Read

Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations.Semantic proximity Read