Article
Apolipoprotein E (epsilon) genotype has a greater impact on apoB-48 than apoB-100 responses to dietary fat manipulation-insights from the SATgenε study.
Molecular nutrition & food research - 1 Apr 2017
Jackson Kim G, Lockyer Stacey, Carvalho-Wells Andrew L, Williams Christine M, Minihane Anne M, Lovegrove Julie A
Abstract excerpt
SCOPE: To determine the contribution of intestinally and liver-derived lipoproteins to the postprandial plasma triacylglycerol (TAG) response in APOE3/E3 and E3/E4 individuals following chronic dietary fat manipulation. METHODS AND RESULTS: In sequential order, participants (n = 12 E3/E3, n = 11 E3/E4) followed low fat; high-fat, high-saturated fat (HSF); and HSF with 3.45 g/day docosahexaenoic acid (HSF-DHA)...
Topics
- Adult
- Apolipoprotein B-100
- Apolipoprotein B-48
- Apolipoprotein E3
- Apolipoproteins B
- Apolipoproteins E
- Diet, Fat-Restricted
- Dietary Fats
- Docosahexaenoic Acids
- Fatty Acids
- Female
- Genotype
- Humans
- Male