Article
Two independent apolipoprotein A5 haplotypes modulate postprandial lipoprotein metabolism in a healthy Caucasian population.
The Journal of clinical endocrinology and metabolism - 1 Jun 2007
Moreno-Luna Rafael, Perez-Jimenez Francisco, Marin Carmen, Perez-Martinez Pablo, Gomez Purificacion, Jimenez-Gomez Yolanda, Delgado-Lista Javier, Moreno Juan A, Tanaka Toshiko, Ordovas Jose M, Lopez-Miranda Jose
Abstract excerpt
BACKGROUND: Apolipoprotein A5 (APOA5) plays an important role in plasma triacylglycerol (TG) homeostasis. Five polymorphisms (1131T>C, c.-3A>G, c.56C>G, IVS3+476G>A, and c.1259T>C) in the APOA5 gene define three common haplotypes (APOA5*1, APOA5*2, and APOA5*3) in Caucasian individuals. Our aim was to determine whether these haplotypes could modulate the postprandial response in young healthy males. DESIGN AND...
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