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Article

Apolipoprotein E (APOE) genotype regulates body weight and fatty acid utilization-Studies in gene-targeted replacement mice.

Molecular nutrition & food research - 1 Feb 2015

Huebbe Patricia, Dose Janina, Schloesser Anke, Campbell Graeme, Glüer Claus-Christian, Gupta Yask, Ibrahim Saleh, Minihane Anne-Marie, Baines John F, Nebel Almut, Rimbach Gerald

Abstract excerpt

SCOPE: Of the three human apolipoprotein E (APOE) alleles, the ε3 allele is most common, which may be a result of adaptive evolution. In this study, we investigated whether the APOE genotype affects body weight and energy metabolism through regulation of fatty acid utilization. METHODS AND RESULTS: Targeted replacement mice expressing the human APOE3 were significantly heavier on low- and high-fat diets compared...

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Source

Identifiers

PMID: 25381750
DOI: 10.1002/mnfr.201400636

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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