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Article

PATZ1 down-regulates FADS1 by binding to rs174557 and is opposed by SP1/SREBP1c.

Nucleic acids research - 17 Mar 2017

Pan Gang, Ameur Adam, Enroth Stefan, Bysani Madhusudhan, Nord Helena, Cavalli Marco, Essand Magnus, Gyllensten Ulf, Wadelius Claes

Abstract excerpt

The FADS1 and FADS2 genes in the FADS cluster encode the rate-limiting enzymes in the synthesis of long-chain polyunsaturated fatty acids (LC-PUFAs). Genetic variation in this region has been associated with a large number of diseases and traits many of them correlated to differences in metabolism of PUFAs. However, the causative variants leading to these associations have not been identified. Here we find that...

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Source

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Identifiers

PMID: 27932482
DOI: 10.1093/nar/gkw1186
PMCID: PMC5389558

Genes

FADS1
PATZ1
FADS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PATZ1 down-regulates FADS1 by binding to rs174557 and is opposed by SP1/SREBP1c.PMID 27932482Read ↗

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