Article
The BAF45a/PHF10 subunit of SWI/SNF-like chromatin remodeling complexes is essential for hematopoietic stem cell maintenance.
Experimental hematology - 1 Apr 2017
Krasteva Veneta, Crabtree Gerald R, Lessard Julie A
Abstract excerpt
The ability of hemopoietic stem cells to self-renew and differentiate into downstream lineages is dependent on specialized chromatin environments that establish and maintain stage-specific patterns of gene expression. However, the epigenetic factors responsible for mediating these regulatory events remain poorly defined. Here we provide evidence that BAF45a/PHF10, a subunit of SWI/SNF-like chromatin remodeling...
Topics
- Animals
- Biomarkers
- Cell Differentiation
- Cell Self Renewal
- Chromatin Assembly and Disassembly
- Chromosomal Proteins, Non-Histone
- Gene Expression
- Gene Expression Regulation, Developmental
- Gene Order
- Genes, Lethal