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Article

A mutant allele of the Swi/Snf member BAF250a determines the pool size of fetal liver hemopoietic stem cell populations.

Blood - 9 Sept 2010

Krosl Jana, Mamo Aline, Chagraoui Jalila, Wilhelm Brian T, Girard Simon, Louis Isabelle, Lessard Julie, Perreault Claude, Sauvageau Guy

Abstract excerpt

It is believed that hemopoietic stem cells (HSC), which colonize the fetal liver (FL) rapidly, expand to establish a supply of HSCs adequate for maintenance of hemopoiesis throughout life. Accordingly, FL HSCs are actively cycling as opposed to their predominantly quiescent bone marrow counterparts, suggesting that the FL microenvironment provides unique signals that support HSC proliferation and self-renewal. We...

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Identifiers

PMID: 20522713
DOI: 10.1182/blood-2010-03-273862
PMCID: PMC2947392

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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