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The mRNA capping enzyme of Saccharomyces cerevisiae has dual specificity to interact with CTD of RNA Polymerase II.

Scientific reports - 9 Aug 2016

Bharati Akhilendra Pratap, Singh Neha, Kumar Vikash, Kashif Md, Singh Amit Kumar, Singh Priyanka, Singh Sudhir Kumar, Siddiqi Mohammad Imran, Tripathi Timir, Akhtar Md Sohail

Abstract excerpt

RNA Polymerase II (RNAPII) uniquely possesses an extended carboxy terminal domain (CTD) on its largest subunit, Rpb1, comprising a repetitive Tyr1Ser2Pro3Thr4 Ser5Pro6Ser7 motif with potential phosphorylation sites. The phosphorylation of the CTD serves as a signal for the binding of various transcription regulators for mRNA biogenesis including the mRNA capping complex. In eukaryotes, the 5 prime capping of the...

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Identifiers

PMID: 27503426
DOI: 10.1038/srep31294
PMCID: PMC4977518

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The mRNA capping enzyme of Saccharomyces cerevisiae has dual specificity to interact with CTD of RNA Polymerase II.PMID 27503426Read ↗

The length, phosphorylation state, and primary structure of the RNA polymerase II carboxyl-terminal domain dictate interactions with mRNA capping enzymes.Semantic proximity Read ↗

Structural insights to how mammalian capping enzyme reads the CTD code.Semantic proximity Read ↗

Allosteric interactions between capping enzyme subunits and the RNA polymerase II carboxy-terminal domain.Semantic proximity Read ↗

Structure of an mRNA capping enzyme bound to the phosphorylated carboxy-terminal domain of RNA polymerase II.Semantic proximity Read ↗

Interactions between fission yeast mRNA capping enzymes and elongation factor Spt5.Semantic proximity Read ↗

Sub1 contacts the RNA polymerase II stalk to modulate mRNA synthesis.Semantic proximity Read ↗

An unusual eukaryotic protein phosphatase required for transcription by RNA polymerase II and CTD dephosphorylation in S. cerevisiae.Semantic proximity Read ↗

Rpb4/7 facilitates RNA polymerase II CTD dephosphorylation.Semantic proximity Read ↗

Distinct requirement of RNA polymerase II CTD phosphorylations in budding and fission yeast.Semantic proximity Read ↗

Separable functions of the fission yeast Spt5 carboxyl-terminal domain (CTD) in capping enzyme binding and transcription elongation overlap with those of the RNA polymerase II CTD.Semantic proximity Read ↗

Conditional inactivation of mRNA capping enzyme affects yeast pre-mRNA splicing in vivo.Semantic proximity Read ↗

Phospho-site mutants of the RNA Polymerase II C-terminal domain alter subtelomeric gene expression and chromatin modification state in fission yeast.Semantic proximity Read ↗

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