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Article

A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5.

The Journal of biological chemistry - 11 Jul 2003

Yeo Michele, Lin Patrick S, Dahmus Michael E, Gill Gordon N

Abstract excerpt

The transcription and processing of pre-mRNA in eukaryotic cells are regulated in part by reversible phosphorylation of the C-terminal domain of the largest RNA polymerase (RNAP) II subunit. The CTD phosphatase, FCP1, catalyzes the dephosphorylation of RNAP II and is thought to play a major role in polymerase recycling. This study describes a family of small CTD phosphatases (SCPs) that preferentially catalyze...

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PMID: 12721286
DOI: 10.1074/jbc.M301791200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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