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Article

p300-mediated acetylation of TRF2 is required for maintaining functional telomeres

9 Jan 2013

Abstract excerpt

The human telomeric protein TRF2 is required to protect chromosome ends by facilitating their organization into the protective capping structure. Post-translational modifications of TRF2 such as phosphorylation, ubiquitination, SUMOylation, methylation and poly(ADP-ribosyl)ation have been shown to play important roles in telomere function. Here we show that TRF2 specifically interacts with the histone...

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Share to Chromosomal and Genetic Variations
Share to DNA Repair Mechanisms
Share to Telomeres, Telomerase, and Senescence

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Identifiers

PMID: 23307557
DOI: 10.1093/nar/gks1354

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