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Article

Hypermethylation of brain natriuretic peptide gene is associated with the risk of rheumatic heart disease.

Bioscience reports - 28 Feb 2017

Li Ni, Zheng Dawei, Sun Lebo, Shi Huoshun, Zhu Xiuying, Xu Guodong, Wang Qinning, Zhu Caimin, Shao Guofeng

Abstract excerpt

To investigate the contribution of brain natriuretic peptide (BNP) promoter DNA methylation to the risk of rheumatic heart disease (RHD) and the influence of warfarin anticoagulant therapy on BNP methylation levels for RHD patients after surgery. BNP methylation levels were determined by bisulfite pyrosequencing from plasma samples of RHD patients compared with healthy controls. Several factors influencing the...

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Identifiers

PMID: 27920275
DOI: 10.1042/BSR20160408
PMCID: PMC5240589

Genes

RHD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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