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Article

Lower HDAC6 mRNA expression and promoter hypomethylation are associated with RA susceptibility.

Journal of the Formosan Medical Association = Taiwan yi zhi - 1 Aug 2022

Fang Tzu-Jung, Lin Chia-Hui, Lin Yuan-Zhao, Chiu Min-HSi, Li Ruei-Nian, Chan Hua-Chen, Yeh Yao-Tsung, Yen Jeng-Hsien

Abstract excerpt

BACKGROUND/PURPOSE: Recent studies showed that Histone deacetylases 6 (HDAC6) inhibitors could improve arthritis in rheumatoid arthritis (RA) rodent models, whereas lower HDAC6 expression was observed in RA patients' synovial fibroblasts, raising the concerns to use HDAC6 inhibitors to treat RA patients. In the present study, we investigated the involvement of HDAC6 mRNA expression and promoter methylation in RA....

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Share to Arthritis, Rheumatoid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukocytes, Mononuclear

Share to Promoter Regions, Genetic

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PMID: 34732304
DOI: 10.1016/j.jfma.2021.10.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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