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Article

Association of matrix metalloprotease 1, 3, and 12 polymorphisms with rheumatic heart disease in a Chinese Han population.

BMC medical genetics - 20 Feb 2018

Hu Wei, Ye Yujia, Yin Yirui, Sang Peng, Li Linhua, Wang Jing, Wan Wen, Li Rui, Bai Xiangfeng, Xie Yuehui, Meng Zhaohui

Abstract excerpt

BACKGROUND: Rheumatic heart disease (RHD) is an autoimmune disease triggered by acute rheumatic fever (ARF). Matrix metalloproteinases (MMPs) play an important role in the modulation of immune responses. The purpose of this study was to evaluate the association of MMP1, 3, and 12 promoter polymorphisms with RHD in a Han population in Southern China since the 3 genes are localized on the same chromosome and have a...

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Identifiers

PMID: 29458338
DOI: 10.1186/s12881-018-0538-4
PMCID: PMC5819250

Genes

RHD
MMP1
MMP12
MMP3

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