Article
Clinical value of DNA methylation markers in autoimmune rheumatic diseases.
Nature reviews. Rheumatology - 1 Sept 2020
Ballestar Esteban, Sawalha Amr H, Lu Qianjin
Abstract excerpt
Methylation of cytosine residues in DNA, the best studied epigenetic modification, is associated with gene transcription and nuclear organization, and ultimately the function of a cell. DNA methylation can be influenced by various factors, including changes in neighbouring genomic sites such as those induced by transcription factor binding. The DNA methylation profiles in relevant cell types are altered in most...
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