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Profiling Genome-Wide DNA Methylation Patterns in Human Aortic and Mitral Valves

6 Apr 2022

Abstract excerpt

Cardiac valves exhibit highly complex structures and specialized functions that include dynamic interactions between cells, extracellular matrix (ECM) and their hemodynamic environment. Valvular gene expression is tightly regulated by a variety of mechanisms including epigenetic factors such as histone modifications, RNA-based mechanisms and DNA methylation. To date, methylation fingerprints of non-diseased human...

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PMID: 35463757
DOI: 10.3389/fcvm.2022.840647

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