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Article

Hypomethylation of the Interferon γ Gene as a Potential Risk Factor for Essential Hypertension: A Case-Control Study.

The Tohoku journal of experimental medicine - 1 Apr 2018

Bao Xing-Jie, Mao Shu-Qi, Gu Tian-Lun, Zheng Shu-Ying, Zhao Jin-Shun, Zhang Li-Na

Abstract excerpt

Essential hypertension (EH) is a multifactorial disease. Interferon-γ (IFN-γ) plays an important role in the onset of EH through cytokine-mediated systemic inflammatory responses. We aimed to determine whether the methylation status of the IFN-γ gene (IFNG) promoter is involved in the pathogenesis of EH. Six copies of CpG dinucleotides are distributed between 3,203 bp and 3,121 bp upstream from the transcription...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29643275
DOI: 10.1620/tjem.244.283

Genes

IFNG

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