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Hypomethylation of interleukin-6 (IL-6) gene increases the risk of essential hypertension: a matched case-control study.

Journal of human hypertension - 1 Aug 2017

Mao S-Q, Sun J-H, Gu T-L, Zhu F-B, Yin F-Y, Zhang L-N

Abstract excerpt

Essential hypertension (EH) is a chronic disease with clear epigenetic component. Inflammation and endothelial dysfunction have a great role in the development of persistent blood pressure elevation. The aim of this study was to explore an association between EH and DNA methylation in pro-inflammation cytokine gene interleukin-6 (IL-6) during the inflammatory process. We performed methylation analysis of...

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PMID: 28300071
DOI: 10.1038/jhh.2017.7

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