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Article

Thyroid hormone receptors and resistance to thyroid hormone disorders.

Nature reviews. Endocrinology - 1 Oct 2014

Ortiga-Carvalho Tânia M, Sidhaye Aniket R, Wondisford Fredric E

Abstract excerpt

Thyroid hormone action is predominantly mediated by thyroid hormone receptors (THRs), which are encoded by the thyroid hormone receptor α (THRA) and thyroid hormone receptor β (THRB) genes. Patients with mutations in THRB present with resistance to thyroid hormone β (RTHβ), which is a disorder characterized by elevated levels of thyroid hormone, normal or elevated levels of TSH and goitre. Mechanistic insights...

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Source

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Identifiers

PMID: 25135573
DOI: 10.1038/nrendo.2014.143
PMCID: PMC4578869

Genes

THRB
THRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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