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Article

A mouse model of resistance to thyroid hormone produced by somatic gene transfer of a mutant thyroid hormone receptor.

Molecular endocrinology (Baltimore, Md.) - 1 Jan 1996

Hayashi Y, Mangoura D, Refetoff S

Abstract excerpt

Resistance to thyroid hormone (RTH) is a dominantly inherited syndrome characterized by hyposensitivity to thyroid hormone caused by mutations in the thyroid hormone receptor-beta (TR beta) gene. Replication-defective recombinant adenoviruses were constructed that express the human wild-type (WT) TR beta, a human mutant TR beta identified in a family with RTH, and luciferase under the control of thyroid hormone...

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PMID: 8838149
DOI: 10.1210/mend.10.1.8838149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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