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Article

Molecular basis of resistance to thyroid hormone.

Trends in endocrinology and metabolism: TEM - 1 Sept 2003

Yen Paul M

Abstract excerpt

Resistance to thyroid hormone (RTH) is a syndrome in which patients have raised serum thyroid hormone (TH) levels and raised or inappropriately normal thyrotropin (TSH) levels. In general, patients exhibit TH resistance in the pituitary and peripheral tissues. Novel techniques and genetically engineered mouse model systems have increased our understanding of thyroid hormone receptor (TR) action, and shed new...

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PMID: 12946875
DOI: 10.1016/s1043-2760(03)00114-0

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