Article
Novel insight from transgenic mice into thyroid hormone resistance and the regulation of thyrotropin.
The Journal of clinical investigation - 1 Jan 1999
Abel E D, Kaulbach H C, Campos-Barros A, Ahima R S, Boers M E, Hashimoto K, Forrest D, Wondisford F E
Abstract excerpt
Patients with resistance to thyroid hormone (RTH) exhibit elevated thyroid hormone levels and inappropriate thyrotropin (thyroid-stimulating hormone, or TSH) production. The molecular basis of this disorder resides in the dominant inhibition of endogenous thyroid hormone receptors (TRs) by a muta...
Topics
- Animals
- Disease Models, Animal
- Mice
- Mice, Transgenic
- Mutation
- Pituitary Gland
- Protein Precursors
- RNA, Messenger
- Receptors, Thyroid Hormone
- Thyroid Hormone Resistance Syndrome
- Thyrotropin
- Thyrotropin-Releasing Hormone
- Thyroxine
- Triiodothyronine