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Article

Novel insight from transgenic mice into thyroid hormone resistance and the regulation of thyrotropin.

The Journal of clinical investigation - 1 Jan 1999

Abel E D, Kaulbach H C, Campos-Barros A, Ahima R S, Boers M E, Hashimoto K, Forrest D, Wondisford F E

Abstract excerpt

Patients with resistance to thyroid hormone (RTH) exhibit elevated thyroid hormone levels and inappropriate thyrotropin (thyroid-stimulating hormone, or TSH) production. The molecular basis of this disorder resides in the dominant inhibition of endogenous thyroid hormone receptors (TRs) by a mutant receptor. To determine the relative contributions of pituitary versus hypothalamic resistance to the dysregulated...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 9916139
DOI: 10.1172/JCI5205
PMCID: PMC407884

Genes

TRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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