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Article

Novel Mutation (T273R) in Thyroid Hormone Receptor β Gene Provides Further Insight into Cryptic Negative Regulation by Thyroid Hormone.

Folia biologica - 1 Jan 2017

Kaššák F, Hána V, Saudek V, Kostrouchová M

Abstract excerpt

Production of thyroid hormone is precisely regulated in a negative feed-back mechanism that depends critically on thyroid hormone receptor β (TRβ). This mechanism decreases production of thyrotropin- releasing hormone (TRH) and thyrotropin (TSH) in the hypothalamus and pituitary gland in response to high levels of circulating thyroid hormones (TH). Despite the wealth of accumulated knowledge, it is still not...

Topics

Female
Humans
Hypothalamus
Male
Mutation
Thyroid Hormone Receptors beta
Thyroid Hormones
Thyrotropin
Thyrotropin-Releasing Hormone

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 28557707
DOI: 10.14712/fb2017063020060

Genes

TRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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