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Article

Genome-wide survey in African Americans demonstrates potential epistasis of fitness in the human genome.

Genetic epidemiology - 1 Feb 2017

Wang Heming, Choi Yoonha, Tayo Bamidele, Wang Xuefeng, Morris Nathan, Zhang Xiang, Broeckel Uli, Hanis Craig, Kardia Sharon, Redline Susan, Cooper Richard S, Tang Hua, Zhu Xiaofeng

Abstract excerpt

The role played by epistasis between alleles at unlinked loci in shaping population fitness has been debated for many years and the existing evidence has been mainly accumulated from model organisms. In model organisms, fitness epistasis can be systematically inferred by detecting nonindependence of genotypic values between loci in a population and confirmed through examining the number of offspring produced in...

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Source

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Identifiers

PMID: 27917522
DOI: 10.1002/gepi.22026
PMCID: PMC5226866

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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