Article
Revealing evolutionary pathways by fitness landscape reconstruction.
Critical reviews in biochemistry and molecular biology - 1 Jan 2000
Kogenaru Manjunatha, de Vos Marjon G J, Tans Sander J
Abstract excerpt
The concept of epistasis has since long been used to denote non-additive fitness effects of genetic changes and has played a central role in understanding the evolution of biological systems. Owing to an array of novel experimental methodologies, it has become possible to experimentally determine epistatic interactions as well as more elaborate genotype-fitness maps. These data have opened up the investigation of...
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