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Article

Rapid in vivo validation of candidate drivers derived from the PTEN-mutant prostate metastasis genome.

Methods (San Diego, Calif.) - 1 May 2015

Cho Hyejin, Herzka Tali, Stahlhut Carlos, Watrud Kaitlin, Robinson Brian D, Trotman Lloyd C

Abstract excerpt

Human genome analyses have revealed that increasing gene copy number alteration is a driving force of incurable cancer of the prostate (CaP). Since most of the affected genes are hidden within large amplifications or deletions, there is a need for fast and faithful validation of drivers. However, classic genetic CaP engineering in mouse makes this a daunting task because generation, breeding based combination of...

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Source

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Identifiers

PMID: 25592467
DOI: 10.1016/j.ymeth.2014.12.022
PMCID: PMC4429512

Genes

PTEN
FOXP1
RYBP
SHQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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