RTG1 and RTG2: two yeast genes required for a novel path of communication from mitochondria to the nucleus.

doi:10.1016/0092-8674(93)90050-z

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Article

RTG1 and RTG2: two yeast genes required for a novel path of communication from mitochondria to the nucleus.

Cell - 15 Jan 1993

Liao X, Butow R A

Abstract excerpt

The expression of some nuclear genes is sensitive to the functional state of mitochondria, a process we term retrograde regulation. Here we show that retrograde regulation of the yeast CIT2 gene encoding peroxisomal citrate synthase depends on a new class of upstream activation site element (UASr...

Topics

Amino Acid Sequence
Base Sequence
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Cell Nucleus
Citrate (si)-Synthase
Cloning, Molecular
DNA, Fungal
DNA-Binding Proteins
Fungal Proteins
Gene Expression Regulation, Fungal
Genes, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Regulator

Glycerol

Intracellular Signaling Peptides and Proteins

Microbodies

Mitochondria

Molecular Sequence Data

Mutation

Source

Open in PubMed

Identifiers

PMID: 8422683
DOI: 10.1016/0092-8674(93)90050-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8422683-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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RTG1 and RTG2: two yeast genes required for a novel path of communication from mitochondria to the nucleus.PMID 8422683Read ↗

RTG genes in yeast that function in communication between mitochondria and the nucleus are also required for expression of genes encoding peroxisomal proteins.Semantic proximity Read ↗

A transcriptional switch in the expression of yeast tricarboxylic acid cycle genes in response to a reduction or loss of respiratory function.Semantic proximity Read ↗

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Interorganellar communication. Altered nuclear gene expression profiles in a yeast mitochondrial dna mutant.Semantic proximity Read ↗

The retrograde response links metabolism with stress responses, chromatin-dependent gene activation, and genome stability in yeast aging.Semantic proximity Read ↗

The Saccharomyces cerevisiae RTG2 gene is a regulator of aconitase expression under catabolite repression conditions.Semantic proximity Read ↗

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Regulation of respiratory growth by Ras: the glyoxylate cycle mutant, cit2Delta, is suppressed by RAS2.Semantic proximity Read ↗

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