Article

A mitochondrial electron transport chain with atypical subunit composition confers oxygen sensitivity to a mammalian chemoreceptor

2021-10-05

Abstract excerpt

The carotid body (CB) is the major chemoreceptor for blood oxygen in the control of ventilation in mammals, contributing to physiological adaptation to high altitude, pregnancy, and exercise, and its hyperactivity is linked to chronic conditions such as sleep-disorder breathing, hypertension, chronic heart failure, airway constriction, and metabolic syndrome ( 1–3 ). Upon acute hypoxia (PO 2 =100 mmHg to <80 mmH...

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Literature Corpus work: 74374a12-e305-556e-ab74-acb769132cb3
DOI: 10.1101/2021.10.04.463079

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