Article
Retrograde signaling is regulated by the dynamic interaction between Rtg2p and Mks1p.
Molecular cell - 1 Aug 2003
Liu Zhengchang, Sekito Takayuki, Spírek Mário, Thornton Janet, Butow Ronald A
Abstract excerpt
Activation of retrograde signaling (RS) by mitochondrial dysfunction or by inhibition of TOR kinases in yeast results in nuclear accumulation of the transcription factors, Rtg1p and Rtg3p. This process requires Rtg2p, a novel cytoplasmic protein with an N-terminal ATP binding domain. We show that Rtg2p controls RS by reversibly binding a negative regulator, Mks1p. The inhibitory form of Mks1p is phosphorylated...
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